%A TIAN Hui, ZHANG Dan-shen
%T <strong>Progress on the Neuroprotective Mechanism of Gastrodin</strong>
%0 Journal Article
%D 2013
%J ACTA NEUROPHARMACOLOGICA
%R 
%P 58-64
%V 3
%N 5
%U {http://actanp.hebeinu.edu.cn/CN/abstract/article_230.shtml}
%8 2013-10-26
%X Gastrodin is a main chemical constituent in Gastrodia elata blume and has been widely used in clinical application with various therapeutic effects. Current studies suggest that gastrodin has analgesic, sedative, hypnosis, anti- convulant, antiepileptic, antineurodegenerative diseases, and so on. Its mechanism of action is not fully understood, yet existing results suggest that its neuroprotective mechanism is closely related to inhibiting the activation of astrocytes, reducing the expression of CGRP, lowering DRG excitability, activating benzodiazepine receptor, reducding the amount of dopamine and norepinephrine, balancing the amino acid neurotransmitter, and inhibiting brain synaptic remodeling in the brain.