|星空彩票电脑版
%A WANG Zhen-zhen, CHEN Nai-hong %T
Depression and Inflammation%0 Journal Article %D 2013 %J ACTA NEUROPHARMACOLOGICA %R %P 27-37 %V 3 %N 5 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_226.shtml} %8 2013-10-26 %X Depression is the affective disorder characterized by a state of low mood, pessimism, cognitive and sleep disorders. Despite the widespread prescription of monoaminergic neurotransmitter modulators, the monoamine hypothesis cannot explain all the phenomena of depression. Moreover, limited drug efficacies, slow onset of action and undesirable side effects have made urgent the task of discovering novel therapeutics. Thus, several hypotheses other than the monoamine hypothesis have received much attention in recent years. The inflammatory hypothesis of depression is that inflammatory mechanisms play a crucial role in the pathophysiological mechanisms of major depression. This review will focus on progress of the (neuro)inflammatory hypothesis of depression.