%A ZHANDSUN Dong-ting, LUO Su-lan
%T <strong>Development of Human Experimental Pain Models</strong>
%0 Journal Article
%D 2013
%J ACTA NEUROPHARMACOLOGICA
%R 
%P 13-26
%V 3
%N 5
%U {http://actanp.hebeinu.edu.cn/CN/abstract/article_225.shtml}
%8 2013-10-26
%X Pain is the most common symptom of various diseases, which is a vexing worldwide problem that causes substantial disability and consumes significant medical resources. Limited analgesic medications were used in the clinic. The effects of these analgesics are often incomplete and complicated by serious side effects and/or tolerance. Thus, new types of analgesic drugs without addiction and serious side effects are desperately needed. It is hard to understand the basic biology of pain as well as to evaluate analgesic effects in human models. Therefore, animal models are widely used in the laboratory investigations to screen and identify new painkiller candidates. Animal pain models have shown low predictability for analgesic efficacy in humans, and clinical studies are confounded to interfere with the evaluation. Human experimental pain models may therefore help to evaluate mechanisms and effect of analgesics and bridge findings from basic studies to the clinic. The value of human experimental pain models is to link animal and clinical pain studies, providing new possibilities for designing successful clinical trials. The present review outlines the progress of human experimental pain models in healthy volunteers and addresses analgesic efficacy in patients, which would be helpful to speed up development of new types of analgesic drugs.