|星空彩票电脑版
%A LIU Liang-jing, SHEN Li-xia %T
An Update on Neuroprotective Effects of Estrogen in Alzheimer's Disease%0 Journal Article %D 2013 %J ACTA NEUROPHARMACOLOGICA %R %P 58-64 %V 3 %N 4 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_224.shtml} %8 2013-08-26 %X Alzheimer's disease is a disease caused by a variety of CNS-degenerating factors, characterized by deposition of amyloid beta and hyperphosphorylation of tau protein. Estrogen can inhibit neuronal cell apoptosis by inhibiting the activity of caspase, regulating of Bax and Bcl-2 expression and the ratio, increasing the content of cAMP in hypothalamic neurons and glial cells, promoting the rapid cAMP response element-binding protein (CREB) phosphorylation, influencing the N-methl-D-aspartate (NMDA) receptor expression in hippocampal cells. Estrogen also exerts direct protective effect on neuron cells by brain-derived neurotrophic factor and synaptophysin.