|星空彩票电脑版
%A LI Ying-jie，YANG Bao-xue %T
Anesthetic Mechanism, Its Protective Effect and Ion Channels%0 Journal Article %D 2013 %J ACTA NEUROPHARMACOLOGICA %R %P 39-46 %V 3 %N 4 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_222.shtml} %8 2013-08-26 %X Anesthetics have been widely used in clinical surgeries, but their detailed mechanisms are still unclear. With the application of some new techniques, it is found that the ion channels are involved in anesthetic mechanisms, such as the suppression of N-methyl-D-aspartate channel and neuronal nicotinic acetylcholine receptors, inhibition of opening the voltage-gated ion channels function, and enhancing the GABAA-R channels. In addition, the protective effects of anesthetics on organs are also related with ion channels, which can be realized via activating potassium channels, attenuating calcium influx and so on. This article reviews the relationship between the anesthetics and ion channels in these two aspects.