|星空彩票电脑版
%A PU Ju, YAO Sheng-tao %T
Research Progress of the Neroprotective Mechanism of Ischemic Postconditionining%0 Journal Article %D 2013 %J ACTA NEUROPHARMACOLOGICA %R %P 29-34 %V 3 %N 4 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_220.shtml} %8 2013-08-26 %X Extending the thrombolysis time window and reducing reperfusion injury are problems urgently needed to be solved in ischemic cerebrovascular disease. Ischemic postconditioning provides a possible solution, which has been becoming a hot research topic. Postconditioning, which refers to a series of brief occlusions and reperfusions of the blood vessels, is conducted after ischemia/reperfusion. Postconditioning can induce organ's endogenous protective effects against ischemia reperfusion injury. This article will discuss the neuroprotective mechanism of ischemic postconditioning: reduction of brain blood flow changes after ischemia reperfusion, attenuation of ROS production and apoptosis, anti-inflammatory, and changes in pathways involved in neuronal death after stroke.