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%A ZHAO Wei, WANG Shu, LI Fang-jiang %T
Progress in Understanding the Multiple Organ Injury Induced by Cerebral Ischemia-reperfusion%0 Journal Article %D 2014 %J ACTA NEUROPHARMACOLOGICA %R %P 55-64 %V 4 %N 2 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_210.shtml} %8 2014-04-26 %X Acute ischemic cerebrovascular diseases such as cerebral infarction and cerebral hemorrhage are common and frequently-occurring diseases among the aged people with high mortality rate. After the attack of the ischemic cerebrovascular disease, some organ function would damage and fail, and even worse the occurrence of multiple organs function damage and failure. The failure of various organs causes the aggravation of the original brain lesions, further leading to aggravated multiple organs dysfunction with the emergence of a vicious spiral and even death. Accordingly, it is important to study the prevention and treatment of the multiple organ injury induced by cerebral ischemia-reperfusion. This review focused on the research progress in understanding organ injury such as heart, lung, liver, kidney, gastrointestinal tract, spleen and other organs, hemodynamic changes, and dysfunction of extremities induced by cerebral ischemia-reperfusion. A novel concept on cerebral ischemia-reperfusion was also discussed.