|星空彩票电脑版
%A Huang Min, Tang Tie-shan, Guo Cai-xia %T
Translesion DNA Synthesis and Its Potential Role in Cancer Therapy%0 Journal Article %D 2014 %J ACTA NEUROPHARMACOLOGICA %R %P 36-43 %V 4 %N 5 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_186.shtml} %8 2014-10-26 %X Translesion DNA synthesis (TLS) is an evolutionarily conserved mechanism of DNA damage tolerance in response to DNA damage, which utilizes specialized DNA polymerases to replicate damaged DNA templates. As TLS can tolerate DNA damages, decrease the sensitivity of cancer cells to chemotherapy drugs or ionizing radiation, it is a potential mechanism for cancers to develop drug resistance or radiation resistance. Therefore, it is plausible to target TLS pathway to enhance the therapeutic effect on patients with different tumors, including glioblastoma.