|星空彩票电脑版
%A CHU Shi-feng, ZHANG Jun-tian %T
A New Type of Anti-dementia Drug: The Chemistry, Biological Activities and Mechanism of Action of (-) Clausenamide%0 Journal Article %D 2014 %J ACTA NEUROPHARMACOLOGICA %R %P 33-43 %V 4 %N 6 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_179.shtml} %8 2014-12-26 %X Seven novel amides were isolated from clausena lansium (Lour) skeels, one of which is clausenamide. Clausenamide contains 4 chiral centers, which correspond to 16 enantiomers. After the identification of the configuration of 16 enantiomers, all were successfully synthesized, and the asymmetric synthesis of (+) and (-) clausenamide were completed. During this process, the production scale has been substantially increased that should be adequate to meet the clinical use. Pharmacological studies have shown that (-) clausenamide is the effective enantiomer, while (+) clausenamide is ineffective and more toxic than (-)clausenamide using different animal models. (-)clausenamide can increase cognitive function and inhibit Aβ pathology. The anti-dementia mechanism is characterized as increasing synaptic function and structural plasticity. . Together, (-)clausenamide may be a promising pharmacotherapy for the treatment of AD and other neurodegenerative disorders.