|星空彩票电脑版
%A LIU Ting-ting, SUN Fang-ling, AI Hou-xi, ZHANG Li, WANG Wen %T
Effects of Morroniside on the expression of CyclinD1 and Cdk6 in Hippocampus of Rats with Focal Cerebral Ischemia/Reperfusion Injury%0 Journal Article %D 2013 %J ACTA NEUROPHARMACOLOGICA %R %P 1-7 %V 3 %N 4 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_157.shtml} %8 2013-08-26 %X
Objective: To explore the effects of morroniside on key cell-cycle regulator proteins in a rat model of focal cerebral ischemia-reperfusion.
Methods: After the model of middle cerebral artery occlusion (MCAO) was established, 15 Sprague-Dawley rats were randomly assigned into sham group, model group, morroniside low dose (30 mg·kg-1) group, morroniside middle dose (90 mg·kg-1) group and morroniside high dose (270 mg·kg-1) group. Immunohistochemistry staining was used to measure the expression of CyclinD1 and Cdk6 in ischemic ipsilateral hippocampus.
Results:Compared with sham group, the expression of CyclinD1 and Cdk6 were significantly increased in vehicle-treated ischemic-reperfusion rats. However, the expression of CyclinD1 and Cdk6 was significantly reduced by treatment of morroniside at doses of 90 mg·kg-1 and 270 mg·kg-1 after ischemia-reperfusion.
Conclusion: Morroniside might play a role of neuroprotection by downregulating the expression of CyclinD1 and Cdk6 after cerebral ischemia-reperfusion.