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%A YIN Ming, WANG Ze-jian, ZHAO Wen-juan %T
From Curcumin Toward Treatment of Alzheimer’s Disease: Some Thoughts on New Drug Discovery%0 Journal Article %D 2014 %J ACTA NEUROPHARMACOLOGICA %R %P 1-7 %V 4 %N 2 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_155.shtml} %8 2014-04-26 %X During the last two decades， the story of vigorous curcumin R&D from activity assay to pre-clinical and clinical trials for Alzheimer’s disease and to final failure represents a chaotic thinking on pharmaceutical drug development. The research goals of pharmacologically involved compounds are usually as follows: to observe and record the activity spectrum of synthesized or isolated molecules; to advance drug candidate development based on activity，pharmacodynamic and pharmacokinetic data; to study the mechanism of action of druggable compound; and to participate in the basic biomedical research with the compound as a tool after the mechanism has been well known. Therefore， to avoid the waste of research resources and time，it is necessary for people to set up a clear goal，compare the chemical structures and exhaustively review the literature before a compound is going to be studied.