|星空彩票电脑版 %A QIU Yan-yan, LI Jun-xu, HE Xiao-hua %T The Neuropharmacology of Imiazoline-I₂Receptors%0 Journal Article %D 2013 %J ACTA NEUROPHARMACOLOGICA %R %P 48-64 %V 3 %N 1 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_149.shtml} %8 2013-02-26 %X Imidazoline-I ₂receptor is a group of non-G protein-coupled receptors (GPCR). Its physiological function and clinical significance remains elusive. Accumulating evidence has implicated the imidazoline-I ₂receptors in a wide range of behavioral effects, including analgesia, antidepressant-like effects, modulation of μ opioid receptors and neuroprotection. Here, we provided an updated overview of its location, molecular structure, signal transduction, endogenous ligands, synthetic ligands and related neuropharmacological effects.

map