|星空彩票电脑版
%A WEN Rui-ting ZHANG Han-ting LIANG Jian-hui %T
Phosphodiesterase-4 (PDE4)：the Potential Therapeutic Target for Alcohol Dependence%0 Journal Article %D 2013 %J ACTA NEUROPHARMACOLOGICA %R %P 23-27 %V 3 %N 1 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_146.shtml} %8 2013-02-26 %X Alcohol dependence is a psychiatric disease, which leads to serious individual and social harms. Latest advances in neurobiological research indicate the important role of cyclic adenosine monophosphate (cAMP) signal transduction in the development of alcohol drinking behavior. As a member of the phosphodiesterase (PDE) super family, PDE4 specifically catalyzes the hydrolysis of cAMP and represents a key point in regulating intracellular cAMP levels. Accumulating studies show that PDE4 inhibitors may be a novel class of pharmacotherapies for alcohol dependence. Here we review the existing evidence that support PDE4 as a novel theraputic target for alcohol dependence.