|星空彩票电脑版
%A YANG Hui, TAN Xiao-hong %T
The Effects of Soluble Epoxide Hydrolase Inhibitors on Cardiovascular and Cerebrovascular System Disease%0 Journal Article %D 2012 %J ACTA NEUROPHARMACOLOGICA %R %P 40-44 %V 2 %N 5 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_130.shtml} %8 2012-10-26 %X Arachidonic acid is metabolized to epoxyeicosatrienoic acids (EETs) by cytochrome P450 epoxygenase. EETspromote angiogenesis and
inhibit inflammatory processes and platelet aggregation. EETs are rapidly degradated by soluble epoxide hydrolase (sEH) and their biological activity decreased. Therefore, sEH may be used as a therapeutic target in hypertension, myocardial infarction, renal diseases and ischemic stroke. This review summarized the effects of sEH inhibitors on hypertension, atherosclerosis, cerebral ischemic stroke and chronic heart failure, and discussed the mechanisms of the effects.