|星空彩票电脑版
%A SONG Jin-yan, ZHANG Li, ZHAO Xiao-qian, SONG Zhi-bin %T Effects of Chrysophanol Liposomes on Apoptosis of the Hippocampal Neurons in Mice after Cerebral Ischemia and Reperfusion Injury %0 Journal Article %D 2011 %J ACTA NEUROPHARMACOLOGICA %R %P 7-13 %V 1 %N 2 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_12.shtml} %8 2011-04-26 %X
Objective:To observe the influence of chrysophanol liposomes on apoptosis of hippocampal neurons in mice and to study the protective effects on cerebral ischemia and reperfusion injury and its mechanism.
Methods:Cerebral ischemia and reperfusion injury was produced in conscious mice by temporarily obstructing bilateral common carotid arteries. Chrysophanol liposomes（10.0，1.0，0.1 mg· kg
-1）was injected intraperitoneally. The effects of chrysophanol liposomes were studied on the neurological function, the pathomorphology of brain tissues and the expression of apoptosisrelated protein caspase-3, Bcl-2 and Bax in hippocampal neuron using immunohistochemistry.
Results： Chrysophanol liposomes could increase the expression of Bcl-2, decrease the expression of Bax and caspase-3, improve the neurological function score and decrease the pathological change in chrysophanol liposomes treated animals. The effect of chrysophanol liposomes was most obviously in group 10.0 mg· kg
-1（
P<0.05）.
Conclusion: Chrysophanol liposomes have a significant protective effect on hippocampal neurons after cerebral ischemia and reperfusion injury. The mechanism may be related to increasing the expression of Bcl-2, reducing caspase-3 and Bax.