|星空彩票电脑版
%A ZHENG Li-qing，LIU Jian-hua，ZHANG Dan-shen，WU Hai-xia，XUE Gui-ping %T
Characterization on Tissue Distribution of Osthol In Vivo in Rats by Trapezoidal Area Method%0 Journal Article %D 2012 %J ACTA NEUROPHARMACOLOGICA %R %P 13-18 %V 2 %N 4 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_116.shtml} %8 2012-08-26 %X
Objective:To study the tissue distribution of ostholon rats and to provide bases for clinical applications.
Methods:After osthol was administered to rats (30, 120 mg·kg
-1;ip), the concentration of osthol in rat tissues after different time was determined by RP-HPLC.
Results:Osthol distributed rapidly in the tissues after ip: eight tissues can detect osthol after 5 min. Heart, liver, lung and kidney all reached C
maxin 10 min
.When the dose is increased 4 folds, T
peaksof osthol in tissues had no significant changes, except the concentration and elimination time increased slightly corresponding to the same time-point.
Conclusion:Osthol was distributed rapidly and extensively in the rat’s body and may pass through blood-brain-barrier and blood-testis-barrier.