|星空彩票电脑版 %A ZHANG Ting-ting，LIU Li-ping，JIANG Li-ying，HU Wei，LONG Yan，HONG Hao %T Rosiglitazone Improves Cognitive Impairment in Streptozotocin-induced Diabetic Mice and its Mechanisms %0 Journal Article %D 2011 %J ACTA NEUROPHARMACOLOGICA %R %P 1-6 %V 1 %N 2 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_11.shtml} %8 2011-04-26 %X Objective: To investigate the effects of rosiglitazone on cognitive function in streptozotocin-induced diabetic mice and the underlying mechanisms. Methods: Diabetic mice induced by a single intravenous injection of streptozotocin（150 mg• kg ^-1body weigh）were used as animal model of type 1 diabetes. Diabetic mice with hyperglycemia（>11.1 mmol•L ^-1）were randomly divided into three groups,including untreated diabetes group, rosiglitazone( 3.2 mg•kg ^-1and 1.6 mg•kg ^-1)treated groups（10~12 mice/group）. After orally administration of rosiglitazone for 6 w, rosiglitazone-treated diabetic mice, untreated diabetic mice and non-diabetic controls were tested in the Morris water maze and Y maze. The serum insulin，the levels of Aβ ₄₀，Aβ ₄₂and BACE1 in hippocampus and cortex were determined by ELISA assays，and the blood glucose was measured by the glucose oxidase method. Results: Both water maze and Y maze learning were impaired in diabetic mice. In Morris water maze, rosiglitazone（3.2 mg• kg ^-1）significantly decreased the escape latency（ P<0.05）and increased the time spent in the platform quadran（ P<0.05）compared with the vehicle diabetic group. Rosiglitazone（3.2 mg• kg ^-1）also significantly increased the number of correct（ P<0.05）in Y maze test. Rosiglitazone treatment did not decrease the blood glucose and serum insulin of diabetic mice. Rosiglitazone（3.2 mg• kg ^-1）significantly decreased the Aβ ₄₀（ P<0.05, P<0.05）and Aβ ₄₂（ P<0.05, P<0.05）levels in both hippocampus and cerebral cortex of diabetic mice, without reducing the increased BACE1 level. Conclusion: Rosiglitazone at the dosage of 3.2 mg• kg ^-1improves cognitive impairments in streptozotocin-induced diabetic mice via the alleviation of the Aβ burden in the brain.

map