|星空彩票电脑版
%A WEI Hui-ping, ZHU Deng- xiang, ZHANG Ai-lan, SONG Xiao-qing, CUI Le %T
Repairment ofIn VitroInduced Neuron-like Cells on the Brain Injury in Rats%0 Journal Article %D 2013 %J ACTA NEUROPHARMACOLOGICA %R %P 20-24 %V 3 %N 6 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_106.shtml} %8 2013-12-26 %X
Objective:To investigate the effect of neuron-like cells induced from bone marrow mesenchymal stem cells (BMSC) inthe repairment of brain injury in rats.
Methods:BMSCs were isolated and cultured from rat's bone marrow by adherent method, identified by flow cytometry. BMSCs were induced into neuron-like cells using ligustrazine. 24 hrs after Neuron-like cell induction, the cells were directly transplanted into the hippocampus of rats with brain injury, and the survival of neuron-like cells in microenvironment of nervous system and pathological changes was examined.
Results:Compared to rats with brain injury alone, rats that received neuron-like cells transplantation showed a decreased number of nerve cell degeneration and necrosis and less significant interstitial edema.
Conclusion: rats with brain injury.Neuron-like cells induced from BMSC can improve brain function of