Objective：To explore the therapeutic effect of ultrasound microbubble-assisted therapy on cerebral ischemia-reperfusion injury in rats. Methods: A rat cerebral ischemiareperfusion model was prepared by the wire thrombus method. 40 successfully modeled rats were randomly divided into a microbubble group (ultrasound irradiation+microbubble+thromb olysis) and a control group (ultrasound irradiation+thrombolysis), with 20 cases in each group. Both groups of rats received treatment at a frequency of 1 times·d-1 for 15 days. At the end of thrombolysis treatment, thrombus clearance scores, severity of neurological damage, and water content of the brain tissue were compared between the two groups. Results: Thrombus clearance score in the microbubble group was higher than that in the control group at 3 and 6 h after grouping (P<0.05). mNSS scores in the microbubble group were lower than that in the control group on the 10th and 15th day after grouping (P<0.05). The water content of brain tissue in the microbubble group was lower than that in the control group on the 8th day after grouping (P<0.05). Conclusion: Ultrasound combined with microbubbles for cerebral ischemia-reperfusion rats contributes to thrombus clearance and is able to attenuate neurological damage and brain tissue water content.