Objective：To investigate the regulatory mechanism of Xijiao Dihuang decoction on coagulation function in septic rats. Methods： Ninety rats were randomly divided into treatment group， model group and sham operation group， with 30 rats in each group. The sepsis model was established by cecal ligation and puncture in the treatment group and the model group， and the cecum was gently turned without ligation and puncture in the sham-operation group. After successful modeling， the treatment group was given Xijiao Dihuang decoction by gavage， and the model group and sham operation group were given normal saline by gavage for 3 consecutive days. Plasma tissue factor（ TF）， antithrombin-III（ AT-Ⅲ）， activated protein C（ APC）， tissue factor pathway inhibitor （TFPI） and plasminogen activator inhibitor-1 （PAI-1） levels were detected by ELISA AT 24， 48 and 72 hours after gavage in the treatment group， model group and sham operation group. Results： There was no significant difference in TF， AT-Ⅲ， APC， TFPI and PAI-1 between the sham operation group and the control group AT 24， 48 and 72 h （P>0.05）. Compared with the sham operation group， TF， TFPI and PAI-1 in the model group increased and AT-Ⅲ and APC decreased AT 24， 48 and 72 h， and the differences were statistically significant （P<0.05）. In the model group， TF， AT-Ⅲ， APC， TFPI and PAI-1 showed progressive changes with time AT 24， 48 and 72 h， and the differences were statistically significant （P<0.05）. Compared with the model group， TF and PAI-1 in the treatment group decreased， while AT-Ⅲ， APC and TFPI increased AT 24， 48 and 72 h， and the differences were statistically significant （P<0.05）. The levels of TF， AT-Ⅲ， APC， TFPI and PAI-1 in the treatment group AT 24， 48 and 72 h showed progressive changes with time， and the differences were statistically significant （P<0.05）. Conclusion： The mechanism by which Xijiao Dihuang Decoction regulates coagulation function is related to the decrease of TF and PAI-1 and the increase of AT-Ⅲ， APC， and TFPI in septic rats， but further exploration is needed.