|星空彩票电脑版
%A YANG Ying-Lin，CHENG Xiao，LI Wei-Han，LIU Man，WANG Yue-Hua，DU Guan-Hua %T
KAE Alleviates LPS-induced Neuroinflammation in the Striatum of Mice via Down-regulating TLR4/ MyD88 Signaling Pathway%0 Journal Article %D 2018 %J 神经药理学报 %R %P 30-30 %V 8 %N 2 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_416.shtml} %8 2018-04-26 %X Objective：Kaempferol（ KAE） is a natural fl avonoid with many biological activities including anti-oxidation and anti-inflammation. Nevertheless，the relevant mechanism of its antineuroinfl ammation remains unclear. The present study was to investigate the mechanism of KAE against LPS-induced neuroinfl ammation in the striatum of mice. Methods：Lipopolysaccharide （LPS），a lipid polysaccharide，can be used to establish animal inflammation model. Adult male BALB/c mice were treated with KAE 20 mg·kg-1 and 50 mg·kg-1 for 7 days. On the 7th day，the mice were treated with LPS 5 mg·kg-1 for 6 h. The levels of IL-1β，IL-6，TNF-α，MCP-1 and ICAM-1 in the striatum were determined by ELISA. The protein expression of TLR4，MyD88，HMGB1 and P2X7 in the striatum were detected by Western blotting. Results：KAE significantly decreased cytokines release including IL-1β，IL-6，TNF-α，MCP-1 and ICAM-1 in the striatum of mice induced by LPS. In addition，KAE also inhibited the infl ammatory proteins expression，such as TLR4，MyD88，HMGB1 and P2X7，in the striatum of mice induced by LPS. Conclusion：KAE alleviates LPS-induced neuroinfl ammation in the striatum of mice via inhibiting TLR4/MyD88 signaling pathway.