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摘要/Abstract

摘要：

ATP 敏感钾通道（ATP-sensitive potassium channel，KATP），因其通道活性受ATP/ADP 的影响而得名。KATP 是一种耦联细胞电活动和细胞代谢的特殊通道，通道功能在正常状态下，对于维持神经细胞线粒体膜电位、抑制细胞凋亡有重要作用。KATP 广泛存在于胰岛细胞、心肌、骨骼肌、血管平滑肌和神经细胞等组织中。近几年的研究发现KATP 参与了多种疾病的发病过程，该文对ATP 敏感钾通道在神经退行性疾病中的研究进展作了综述。

关键词:ATP 敏感钾通道,神经退行性疾病,研究进展

Abstract:

The ATP-sensitive potassium channel （KATP） is named because its channel activity is affected by ATP/ADP. KATP is a special channel that couples cell electrical activity and cell metabolism. Under normal conditions，channel function plays an important role in maintaining mitochondrial membrane potential and inhibiting cell apoptosis. KATP is widely found in islets，myocardium，skeletal muscle，vascular smooth muscle，and nerve cells. In recent years，studies have found that KATP is involved in the pathogenesis of a variety of diseases. This article reviews the research progress of ATP-sensitive potassium channels in neurodegenerative diseases.

Key words:ATP-sensitive potassium channels,neurodegenerative diseases,research progress

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R329.25

引用本文

边芳，侯艳宁.ATP 敏感钾通道在神经退行性疾病中的研究进展[J]. 神经药理学报,DOI: 10.3969/j.issn.2095-1396.2017.05.009.

BIAN Fang1，HOU Yan-ning2.Research Progress of the ATP Sensitive Potassium Channels in Neurodegenerative Diseases[J]. Acta Neuropharmacologica,DOI: 10.3969/j.issn.2095-1396.2017.05.009.

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http://actanp.hebeinu.edu.cn/CN/Y2017/V7/I5/52

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ATP 敏感钾通道在神经退行性疾病中的研究进展

Research Progress of the ATP Sensitive Potassium Channels in Neurodegenerative Diseases

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