刘诺，王真真，陈乃宏
出版日期:2017-10-26发布日期:2017-12-01通讯作者:陈乃宏，男，博士，教授；研究方向：神经药理学；Tel：+86-010-63165177，E-mail：chennh@imm.ac.cn作者简介:刘诺，男，硕士；研究方向：神经药理学基金资助:
LIU Nuo，WANG Zhen-zhen，CHEN Nai-hong
Online:2017-10-26Published:2017-12-01Contact:陈乃宏，男，博士，教授；研究方向：神经药理学；Tel：+86-010-63165177，E-mail：chennh@imm.ac.cnAbout author:刘诺，男，硕士；研究方向：神经药理学Supported by:
摘要：
随着人口老龄化程度的加重，阿尔茨海默病（Alzheimer’s disease，AD）的发病率不断上升，然而目前该病的对因治理仍未取得突破。近年来，肠道菌群在AD 发病进程中发挥的作用日益受到关注，肠道菌群的种类和比例随着年龄增加会发生变化，其代谢产物数量改变对认知行为有一定影响，肠道菌群还与脑肠轴双向交流、相互作用。目前，已经证实肠道细菌参与到包括Aβ蛋白沉积、tau 蛋白过度磷酸化、神经炎症、氧化应激损伤、血脑屏障通透性增加、神经递质失平衡、胰岛素抵抗在内的AD 发病机制中。未来，针对致病相关种类的肠道细菌进行特异性调节将是重要的研究方向。
中图分类号:
刘诺，王真真，陈乃宏.肠道菌群在阿尔茨海默病发病中的作用[J]. 神经药理学报,DOI: 10.3969/j.issn.2095-1396.2017.05.005.
LIU Nuo，WANG Zhen-zhen，CHEN Nai-hong.The Role of Gut Flora in the Pathogenesis of Alzheimer’s Disease[J]. Acta Neuropharmacologica,DOI: 10.3969/j.issn.2095-1396.2017.05.005.
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