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神经药理学报››2014,Vol. 4››Issue (4): 42-49.

长链非编码RNA（lncRNAs）的研究策略及其在中枢神经退行性疾病中的研究进展

张钊，楚世峰，黄惠勇，陈乃宏

1.中国医学科学院，药物研究所 & 神经科学中心，天然药物活性物质与功能国家重点实验室，北京，100050，中国
2.湖南中医药大学，长沙，410000，中国

出版日期:2014-08-26发布日期:2015-01-20
通讯作者:陈乃宏，男，研究员，博士生导师，研究方向：神经系统疾患创新药物开发及作用机制，Tel/Fax: 010-63165177, E-mail: chennh@imm.ac.cn
作者简介:张钊，女，博士生，研究方向：神经药理学和神经分子生物学，Tel/Fax: 010-63165182, E-mail：zhangzhao@imm.ac.cn
基金资助:

国家自然科学基金项目（No. 81274122、No. 81102831、No. 81273629、No. 21272278、No. 81473376、No.U1402221），国家“重大新药创制”科技重大专项（No. 2012ZX09301002-004、No. 2012ZX09301002-001-002），国家高技术研究发展计划（863 计划）（No. 2012AA020303），教育部博士点基金重点项目（No. 20121106130001），北京市自然科学基金（No. 7131013、No. 7142115），新药作用机制研究与药效评价北京市重点实验室资助项目（No. BZ0150），协和青年基金和中央高校基本科研业务费专项资金（No. 3332013157）

Long Noncoding RNAs：Research Strategies and Progresses in Neurodegenerative Diseases

Zhang Zhao, Chu Shi-feng, Huang Hui-yong, Chen Nai-hong

1 State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Neuroscience Center, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2 Hunan University Of Chinese Medicine

Online:2014-08-26Published:2015-01-20
Contact:陈乃宏，男，研究员，博士生导师，研究方向：神经系统疾患创新药物开发及作用机制，Tel/Fax: 010-63165177, E-mail: chennh@imm.ac.cn
About author:张钊，女，博士生，研究方向：神经药理学和神经分子生物学，Tel/Fax: 010-63165182, E-mail：zhangzhao@imm.ac.cn
Supported by:

国家自然科学基金项目（No. 81274122、No. 81102831、No. 81273629、No. 21272278、No. 81473376、No.U1402221），国家“重大新药创制”科技重大专项（No. 2012ZX09301002-004、No. 2012ZX09301002-001-002），国家高技术研究发展计划（863 计划）（No. 2012AA020303），教育部博士点基金重点项目（No. 20121106130001），北京市自然科学基金（No. 7131013、No. 7142115），新药作用机制研究与药效评价北京市重点实验室资助项目（No. BZ0150），协和青年基金和中央高校基本科研业务费专项资金（No. 3332013157）

摘要/Abstract

摘要：长链非编码RNA（lncRNAs）是真核细胞中转录本长度超过200 nt的非编码RNA。近年来的研究表明lncRNAs具有一系列的重要功能，包括影响转录、RNA剪切、翻译、核因子转运、基因重排及染色质修饰等，lncRNAs的异常表达常与肿瘤、神经退行性疾病、心血管系统疾病等的发生发展密切相关，因此对lncRNAs的研究将有助于我们对机体生理病理反应的内在机制形成更为系统的认识。本文将就lncRNAs的研究策略及其在神经退行性疾病中的研究进展进行综述，以期为神经系统调控网络的建立及神经退行性疾病的防治提供新的思路。

关键词:长链非编码RNA,研究策略,神经退行性疾病,阿尔茨海默病,帕金森氏病,亨廷顿舞蹈症,肌萎缩侧索硬化症

Abstract:Long noncoding RNAs (lncRNAs) are transcribed RNA molecules greater than 200 nucleotides in length. Nowadays, lncRNAs are found to have lots of functions including regulating transcription, post-transcriptional RNA processing, translation, nuclear factor transport, gene rearrangement and chromatin modification. Abnormal expressions of lncRNAs always come along with the pathogenesis of many diseases, such as cancer, neurodegenerative disorders, and cardiovascular disease. Thus a systematic and comprehensive profiling of lncRNA will help us to have a deeper understanding of the pathogenesis of the diseases. This article will focus on the research strategies of lncRNA and the latest progress in neurodegenerative diseases, which will contribute to the establishment of the regulation network of nervous system, and provide new ideas for the prevention of neurodegenerative diseases.

Key words:long noncoding RNAs,research strategy,neurodegenerative diseases,Alzheimer&,rsquo,s disease,Parkinson&,rsquo,s disease,Huntington&,rsquo,s disease,amyotrophic lateral sclerosis

中图分类号:

R964

张钊，楚世峰，黄惠勇，陈乃宏.长链非编码RNA（lncRNAs）的研究策略及其在中枢神经退行性疾病中的研究进展[J]. 神经药理学报, 2014, 4(4): 42-49.

Zhang Zhao, Chu Shi-feng, Huang Hui-yong, Chen Nai-hong.Long Noncoding RNAs：Research Strategies and Progresses in Neurodegenerative Diseases[J]. Acta Neuropharmacologica, 2014, 4(4): 42-49.

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长链非编码RNA（lncRNAs）的研究策略及其在中枢神经退行性疾病中的研究进展

Long Noncoding RNAs：Research Strategies and Progresses in Neurodegenerative Diseases

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